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April 19 2024 8.27pm

Covid vaccine

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View Mapletree's Profile Mapletree Flag Croydon 16 Jan 21 4.08pm Send a Private Message to Mapletree Add Mapletree as a friend

Originally posted by becky

That's 23 in Norway + the Germans, acknowledged so far......

However, your above post agrees with what I said - it's only now that these problems are coming to light as they always do with any new drug/vaccine/medicine, as clinical trials do not and cannot cover all contingencies.

That does not make me an anti-vaxxer!

We are talking about patients in extremely grave condition, with multiple diseases, who were receiving palliative treatment. I have already said that we are studying these cases ... Based on our current data we assume they died from their main diseases, coinciding in time with the vaccination," Keller-Stanislawski said at a press conference.

 

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View Mapletree's Profile Mapletree Flag Croydon 16 Jan 21 4.12pm Send a Private Message to Mapletree Add Mapletree as a friend

Originally posted by Stirlingsays

Ah...the maple who once didn't like labelling people now can't stop constantly ascribing opinions to others.

I have no objections to the vulnerable and elderly taking vaccines if they so desire. The fact that these vaccinations are beta tests on millions is a judgement for the individual to take.

My personal view is that the vulnerable should take them based upon the balance of probabilities.

For young people, it's not required.

Edited by Stirlingsays (16 Jan 2021 4.07pm)

Of course it's required. I know you are rubbish at logic but I did think you understood science

You think we can just let the virus run free.

Genuinely I despair. There is no freedom of choice here, if a young person exercises it in the 'wrong' direction other people will lose their choices and potentially their lives or at least quality of life.

You have never really been big on shared societal responsibility have you. Each for their own eh? You grew up in a very selfish era.

 

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View Stirlingsays's Profile Stirlingsays Flag 16 Jan 21 4.45pm Send a Private Message to Stirlingsays Holmesdale Online Elite Member Add Stirlingsays as a friend

Originally posted by Mapletree

Of course it's required. I know you are rubbish at logic but I did think you understood science

You think we can just let the virus run free.

Genuinely I despair. There is no freedom of choice here, if a young person exercises it in the 'wrong' direction other people will lose their choices and potentially their lives or at least quality of life.

You have never really been big on shared societal responsibility have you. Each for their own eh? You grew up in a very selfish era.


No, I'm not a communist it's true.

I could temporarily be convinced to be an authoritarian....if we were in the mist of a 'black death' and war of course.

But it's not a suit I wear easily.

Your posts seem to be getting increasingly emotionally erratic.

Must be all those 16 hour shifts.

'You think we can just let the virus run free.'......what you mean like every single virus that have ever existed.

I think instead people like yourself exist in a cloud of hubris in regards to what is possible and the actual cost of that hubris.....which results in far worst longer term outcomes.

But hey...emotion.


Edited by Stirlingsays (16 Jan 2021 4.50pm)

 


'Who are you and how did you get in here? I'm a locksmith. And, I'm a locksmith.' (Leslie Nielsen)

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View Mapletree's Profile Mapletree Flag Croydon 16 Jan 21 5.12pm Send a Private Message to Mapletree Add Mapletree as a friend

Originally posted by Stirlingsays


No, I'm not a communist it's true.

I could temporarily be convinced to be an authoritarian....if we were in the mist of a 'black death' and war of course.

But it's not a suit I wear easily.

Your posts seem to be getting increasingly emotionally erratic.

Must be all those 16 hour shifts.

'You think we can just let the virus run free.'......what you mean like every single virus that have ever existed.

I think instead people like yourself exist in a cloud of hubris in regards to what is possible and the actual cost of that hubris.....which results in far worst longer term outcomes.

But hey...emotion.


Edited by Stirlingsays (16 Jan 2021 4.50pm)

You must live in a yurt

Do you not know anyone that died from Covid-19? Or that’s been in ICU? Or that has long Covid. Or do you just not care?

This isn’t like the flu. Unless you count the Spanish flu.

 

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View Stirlingsays's Profile Stirlingsays Flag 16 Jan 21 5.36pm Send a Private Message to Stirlingsays Holmesdale Online Elite Member Add Stirlingsays as a friend

Originally posted by Mapletree

You must live in a yurt

Do you not know anyone that died from Covid-19? Or that’s been in ICU? Or that has long Covid. Or do you just not care?

This isn’t like the flu. Unless you count the Spanish flu.

I've known one person who died of it and two others who may have died of complications related to it....in other words it weakened them.

I care about many things, as my time on Hol can attest to.....However, the family motto is 'calmness in all things'....though I like to add, 'except in sex and humour'.

So your appeals to emotion within your arguments don't impress me personally.

 


'Who are you and how did you get in here? I'm a locksmith. And, I'm a locksmith.' (Leslie Nielsen)

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View Mapletree's Profile Mapletree Flag Croydon 16 Jan 21 6.46pm Send a Private Message to Mapletree Add Mapletree as a friend

Originally posted by Stirlingsays

I've known one person who died of it and two others who may have died of complications related to it....in other words it weakened them.

I care about many things, as my time on Hol can attest to.....However, the family motto is 'calmness in all things'....though I like to add, 'except in sex and humour'.

So your appeals to emotion within your arguments don't impress me personally.

When did I appeal to emotion

I am appealing to facts. Somehow you don't tend to believe them so I wondered if your personal experience bore any resemblance to the known facts. You historically have said this is just another flu type disease

Here are some facts about that from the Lancet:

89,530 patients with COVID-19 and 45,819 patients with influenza were hospitalised in France during the respective study periods.

The presentation of patients with COVID-19 and seasonal influenza requiring hospitalisation differs considerably. Severe acute respiratory syndrome coronavirus 2 is likely to have a higher potential for respiratory pathogenicity, leading to more respiratory complications and to higher mortality. In children, although the rate of hospitalisation for COVID-19 appears to be lower than for influenza, in-hospital mortality is higher

So more people catch it and a higher proportion of those die.

If it's like the flu then it's as if the flu has been turbo-charged and then a super-charger added on top whilst using a Nitrous Oxide boost kit. These figures pre-date the latest wave and the new strain.

Edited by Mapletree (16 Jan 2021 6.46pm)

 

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View Teddy Eagle's Profile Teddy Eagle Flag 17 Jan 21 1.08pm Send a Private Message to Teddy Eagle Add Teddy Eagle as a friend


Hancock-Up has said the target is now that everyone will have had the first shot by September but refused to confirm the second one would be within 12 weeks. Add on the time for it to be fully effective and that could put us to February 2022 by which time presumably the first to receive the vaccine will be due another dose.

 

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BlueJay Flag UK 17 Jan 21 1.38pm

Originally posted by Teddy Eagle


Hancock-Up has said the target is now that everyone will have had the first shot by September but refused to confirm the second one would be within 12 weeks. Add on the time for it to be fully effective and that could put us to February 2022 by which time presumably the first to receive the vaccine will be due another dose.

There is a flying by the seat of their pants element to who to vaccinate and when, most definitely.

Some interesting data on the Pfizer vaccine after one dose:

"A paper published in the New England Journal of Medicine stated that the efficacy of the Pfizer-BioNTech vaccine was 52.4% between the first and second dose (spaced 21 days apart).5 However, in its “green book” Public Health England said that during the phase III trial most of the vaccine failures were in the days immediately after the first dose, indicating that the short term protection starts around day 10.6 Looking at the data from day 15 to 21, it calculated that the efficacy against symptomatic covid-19 was around 89%."

"The second dose is expected to bring immunity levels to some 95% after about a week".

and the Oxford vaccine:

"In the case of the Oxford-AstraZeneca vaccine, PHE said, “High protection against hospitalisation was seen from 21 days after dose one until two weeks after the second dose, suggesting that a single dose will provide high short term protection against severe disease . . . An exploratory analysis of participants who had received one standard dose of the vaccine suggested that efficacy against symptomatic covid-19 was 73%

There's a lag due to covid incubation period, but the recent Israel study would appear to suggest that people are much less likely to pass on covid post vaccination too, which is a fantastic sign. Vaccination should put a sudden and serious dent in the numbers of new hospitalisations and deaths starting in a couple of months time.

It may be that they'll try to roll out dose two after vaccinating as many people in other groups as possible. If numbers of covid cases within those vaccinated start to creep up at all they might see that as a sign to get moving with it faster. Ideally they will stick to the timescale they'd previously stated, as that would seem optimal, but I've given up second guessing things!

But anyway, my point is that people will hopefully have a substantial degree of protection even if there are some delays, unless it endlessly gets pushed back.

 

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BlueJay Flag UK 17 Jan 21 1.49pm

[Link] - "Vaccine More Effective If Longer Gap Between Doses": Serum To NDTV

"The efficacy of the Covishield vaccine goes up if the gap between two doses is more than 28 days, a top scientist at Adar Poonawalla's Serum Institute of India (SII) said Friday, a day before the launch of India's Covid vaccination drive.

Both the vaccines being used in India - Serum's Covishield and Bharat Biotech's Covaxin - are two dose shots with a prescribed gap of 28 days between the jabs.

Suresh Jadhav, executive director, SII, said results were much better when this gap was increased by a few weeks.

"Even if the difference is of four weeks, it gives good protection, but around 70-80 per cent. If the gap is increased further up to six weeks or eight weeks or 10 weeks, the results are much higher," Dr Jadhav told NDTV.

He explained that the clinical trial was conducted in phase 3 with a 28-day gap, so that became the standard.

But if the second dose was taken faster, it would certainly guarantee 70 per cent protection to the receiver, Dr Jadhav said.

"But if you want protection for a longer period and a higher level, it is better to take it after six to eight weeks," he added."

An interesting new article from India about Covishield, which I believe is the Oxford vaccine.

They appear to believe that the longer left between doses the better, and so if it does turn out that people here are waiting months for the second dose, perhaps it's not an automatic negative. I appreciate that this is only one take on it though, and it's an unknown. If the significant wait between doses evens up actually benefiting more, it will have been more dumb luck than anything really.

Edited by BlueJay (17 Jan 2021 1.49pm)

 

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View Eaglecoops's Profile Eaglecoops Flag CR3 17 Jan 21 2.02pm Send a Private Message to Eaglecoops Add Eaglecoops as a friend

Originally posted by Teddy Eagle


Hancock-Up has said the target is now that everyone will have had the first shot by September but refused to confirm the second one would be within 12 weeks. Add on the time for it to be fully effective and that could put us to February 2022 by which time presumably the first to receive the vaccine will be due another dose.

It’ll be like painting the Forth Bridge. They’ll get to the end and have to start again and this will be the excuse for forever locking us down and keeping pubs closed.

 

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BlueJay Flag UK 17 Jan 21 2.24pm

Originally posted by Eaglecoops

It’ll be like painting the Forth Bridge. They’ll get to the end and have to start again and this will be the excuse for forever locking us down and keeping pubs closed.

There is good reason to believe that the first dose will provide a good level of protection while waiting for the second.. even if it isn't an ideal scenario. Assuming that the number of deaths plummets in a couple of months time, there would be little reason or support for strict lockdowns. It's not going to be a perfect rollout but at least its something they partially appear to be getting right rather than the usual complete disasters. Full steam ahead!

Edited by BlueJay (17 Jan 2021 2.40pm)

 

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View Mapletree's Profile Mapletree Flag Croydon 17 Jan 21 2.38pm Send a Private Message to Mapletree Add Mapletree as a friend

Originally posted by Eaglecoops

It’ll be like painting the Forth Bridge. They’ll get to the end and have to start again and this will be the excuse for forever locking us down and keeping pubs closed.

Yes, we’ll need to be regularly immunised in all likelihood, like with annual flu jabs

Your second point is simply classic of your approach to everything. Get a life will you.

 

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